Subjects “...Cancer Molecular aspects....”

Table of Contents

Subjects “...Alzheimer's disease Molecular aspects....”

Subjects “...Neurobehavioral disorders Genetic aspects....”

Table of Contents

Subjects “...Cancer Molecular aspects....”

Table of Contents “...-- 1.2 Evidence suggests that cancer is a disease of the genome at cellular level -- 1.3 Influential factors in human carcinogenesis -- 1.4 Principles of conventional cancer therapies -- 1.5 Clinical trials -- 1.6 The role of molecular targets in cancer therapies -- 2 DNA structure and stability: mutations versus repair -- 2.1 Gene structure -- two parts of a gene : the regulatory region and the coding region -- 2.2 Mutations -- 2.3 Carcinogenic agents -- 2.4 DNA repair and predispositions to cancer -- Therapeutic strategies -- 2.5 Conventional therapies : chemotherapy and radiation therapy -- 2.6 Strategies that target DNS repair pathways -- 3 Regulation of gene expression -- 3.1 Transcription factors and transcriptional regulation -- 3.2 Chromatin structure -- 3.3 Epigenetic regulation of transcription -- 3.4 Evidence of a role for epigenetics in carcinogenesis -- 3.5 long non-coding RNAs -- 3.6 MicroRNAs (miRNAs) and regulation of mRNA expression -- 3.7 Telomeres and telomerase -- Therapeutic strategies -- 3.8 Epigenomic and histonomic drugs -- 3.9 Non-coding RNAs for diagnosis -- 3.10 Telomerase inhibitors -- 4 Growth factor signaling and oncogenes -- 4.1 Epidermal growth factors signaling: an important paradigm -- 4.2 Oncogenes -- Therapeutic strategies -- 4.3 Kinases as drug targets -- 5 The cell cycle -- 5.1 Cyclins and cyclin-dependent kinases (cdks) -- 5.2 Mechanisms of cdk regulation -- 5.3 Progression through the G1 checkpoint -- 5.4 The G2 checkpoint -- 5.5 The mitotic checkpoint -- 5.6 The cell cycle and cancer -- Therapeutic cancer -- 5.7 Cyclin-dependent kinase inhibitors -- 5.8 Other cell cycle kinase targets -- 5.9 Inhibitors of the mitotic spindle -- 6 Growth inhibitor and tumor suppressor genes -- 6.1 Definitions of tumor suppressor genes -- 6.2 The retinoblastoma gene -- 6.3 Mutations in the RB pathway and cancer -- 6.4 The p53 pathway -- 6.5 Mutations in the p53 pathway and cancer -- 6.6 Interaction of DNA viral protein products with RB and p53 -- Therapeutic strategies -- 6.7 Targeting of the p53 pathway -- 7 Apoptosis -- 7.1 Molecular mechanisms of apoptosis -- 7.2 Apoptosis and cancer -- 7.3 Apoptosis and chemotherapy -- 7.4 Apoptotic drugs -- 8 Cancer stem cells and the regulation of self-renewal and differentiation pathways : focus on colon cancer and leukemias -- 8.1 Cancer stem cells -- 8.2 The regulation of differentiation by gene expression -- Therapeutic strategies -- 8.3 Inhibitors of the Wnt pathway -- 8.4 Inhibitors of the Hh pathway -- 8.5 Inhibitors of PcG proteins -- 8.6 Leukemia and differentiation therapies -- 9 Metastasis -- 9.1 How do tumors spread? ...”