Human molecular genetics / Tom Strachan, Andrew P. Read.

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Bibliographic Details
Edition:Fifth edition.
Published: Boca Raton, Florida : CRC Press, Taylor & Francis Group [2019]
Main Author:
Strachan, T. (Author)
Other Authors:
Format: Book
Table of Contents:
  • Pt. 1: Basics of DNA, chromosomes, cells, development and inheritance
  • Basic principles of nucleic acid structure and gene expression
  • Fundamentals of cells and chromosomes
  • Fundamentals of cell-cell interactions and immune system biology
  • Aspects of early mammalian development, cell differentiation, and stem cells
  • Patterns of inheritance
  • Pt. 2: Understanding genomes
  • Core DNA technologies: amplifying DNA, nucleic acid hybridization, and DNA sequencing
  • Analyzing the structure and expression of genes and genomes
  • Principles of genetic manipulation of mammalian cells
  • Uncovering the architecture and workings of the human genome
  • Gene regulation and the epigenome
  • Pt. 3: Genetic variation between individuals and species
  • An overview of human genetic variation
  • Human population genetics
  • Comparative genomics and genome evolution
  • Human evolution
  • Pt. 4: Human genetic disease
  • Chromosomal abnormalities and structural variants
  • Moleculars pathology: connecting phenotypes to genotypes
  • Mapping and identifying genes for monogenic disorders
  • Complex disease identifying susceptibility factors and understanding pathogenesis
  • Cancer genetics and genomics
  • Pt. 5: Applied human molecular genetics
  • Genetic testing in healthcare and the law
  • Model organisms and modeling disease
  • Genetic approaches to treating disease.